AI is moving from emerging technology to a force reshaping how organizations operate, compete, and manage risk. For CISOs, the challenge is no longer simply understanding the technology, but determining how security must evolve as AI becomes embedded across the enterprise. This keynote will examine the strategic shifts security leaders need to prepare for, including changes to the threat landscape, identity, governance, data protection, workforce models, and the security operating model itself. The focus will be on the decisions CISOs need to make now to stay ahead of rapid change, enable responsible adoption, and ensure the security function remains relevant and effective in an AI-driven enterprise.